Penicillin bottle, also known as borosilicate glass or sodium calcium glass tube (molded) injection bottle, is a small 

bottle sealed with a rubber stopper. It is usually filled with sterile drugs, including powder injection and water injection 

forms. It comes in brown, transparent and other types, and is generally made of low borosilicate glass or neutral

 borosilicate glass material.

Penicillin bottles have good chemical stability, heat resistance, and mechanical strength. They are smooth, transparent,

 easy to clean and disinfect, and have good sealing performance. These physical and chemical properties make it widely 

used in the packaging of various dosage forms in the pharmaceutical industry, meeting the needs of different customers 

for different capacities.

Therefore, it is very important to test the physical properties of penicillin bottles.

Below, the editor of Puchuang Industrial Technology will briefly introduce the equipment for testing penicillin bottles

1、 Penicillin bottle sealing tester

The sealing of penicillin bottles is an important prerequisite for ensuring the shelf life of drugs. There are several types 

of penicillin bottle sealing testers developed and produced by Puchuang Industrial Technology, including:

(1) Negative pressure method penicillin bottle sealing detector

The LT-02P testing instrument for penicillin bottle sealing adopts the principle of negative pressure testing, with stable 

and reliable performance. The automatic constant pressure air supply further ensures that the test can be carried out 

under the preset vacuum conditions, making it suitable for pharmaceutical penicillin bottle sealing testing.

(2) Xilin bottle vacuum decay leak detector

The MLT-V100 leak detector for penicillin bottle vacuum attenuation method adopts non-destructive testing method, 

using both vacuum attenuation and pressure attenuation methods, and is professionally suitable for penicillin bottle 

micro leakage testing and packaging seal integrity testing.

(3) Penicillin bottle microbial invasion sealing tester

The penicillin bottle microbial invasion sealing tester LT-PNP is suitable for microbial invasion sealing tests and is 

widely used in penicillin bottle sealing detection.

2、 Internal stress detection of pharmaceutical penicillin bottles

As is well known, there are stress residues in the annealing process of penicillin bottles. If the stress of penicillin bottles

 is too concentrated at a certain point, it can also cause breakage, cracking, and bottom drop of penicillin bottles on the

 production line.

The SG-03S penicillin bottle internal stress tester developed and produced by Puchuang Industrial Technology uses the

 principle of polarized light interference to check the stress value of penicillin bottles. Combined with the BTG-02 penicillin 

bottle bottom and wall thickness measuring instrument, it can accurately and quantitatively measure the value of internal 

stress in glass.

3、 Determination of vertical axis deviation of penicillin bottles

Vertical axis deviation refers to the horizontal deviation from the center of the bottle mouth to the vertical line passing

 through the center of the bottle bottom. If the vertical axis deviation index of the pharmaceutical penicillin bottle is not 

qualified, problems such as bottle tipping, filling deviation, and labeling deviation may occur during the filling and 

labeling process.

The CRT-01E vertical axis deviation measuring instrument developed and produced by Puchuang Industrial Technology 

is used to detect the vertical axis deviation of penicillin bottles.

4、 Measurement of the thickness of the bottom and wall of penicillin bottles

The wall thickness and bottom thickness of pharmaceutical penicillin bottles not only affect the production cost of 

penicillin bottle manufacturers, but also affect the safety of storage, transportation, and use. Therefore, the testing 

of penicillin bottle wall thickness and bottom thickness is only a testing item that manufacturers pay attention to.

The BTG-02 penicillin bottle bottom and wall thickness measuring instrument produced by Puchuang Industrial 

Technology is used for measuring the thickness of penicillin bottle bottom and wall, also known as penicillin bottle 

wall thickness measuring instrument, etc.

5、 Opening force test of penicillin bottle cap

The opening force of penicillin bottle caps has a significant impact on the usage process. If the opening force is large, 

it will increase the difficulty of use for clinical medical staff. However, if the opening force of bottle caps is small, it will 

also pose a threat to the quality of internal drugs and affect the quality of storage period.

The PNY-20A penicillin bottle cap torque tester produced by Puchuang detects the locking and opening torque values

 of penicillin bottle aluminum-plastic combination caps.

6、 Rubber plug puncture force detection

【 Puncture Force 】 Take 10 pieces of this product and measure them according to the first method of injection stopper 

and gasket puncture force measurement (YBB0033204-2015). The average puncture force should not exceed 75N, and the 

puncture force of each stopper should not exceed 80N. During the puncture process, there should be no stopper pushed 

into the bottle.

Recommendation for rubber plug puncture force tester: Rubber plug puncture force testing machine PMT-C

7、 121 ℃ Particle Water Resistance Test for Medicinal Penicillin Bottles

The experimental method for testing the water resistance of penicillin bottle granules shall refer to the 98 ℃ water resistance

 test method for glass granules and the grading YBB0036204-2015 test, and shall comply with HGBl grade; Glass particles 

should comply with Grade 1 when tested for water resistance at 121 ℃ using the YBB00252003-2015 grading method.

During the measurement process, a professional 121 ℃ particle water resistance tester is required. This testing device is 

designed to test the water resistance of glass bottles, including a grinding bowl and pestle made of quenched steel, as well 

as a set of stainless steel sieves (sieve B: 0.3mm, A: 0.425mm, O: 0.85mm, 0.5mm, one each)