The sealing integrity of drug packaging materials is a mandatory physical indicator written into the drug packaging 

material standards and national drug use standards, and it is also a concern for pharmaceutical manufacturers and 

drug packaging material enterprises. Because the sealing performance of drug packaging materials is related to the

 quality and safety of drugs. If the sealing performance does not meet the standard, external moisture and other 

substances will enter the packaging material and come into contact with the internal drugs, causing the drugs to 

become damp, ineffective, or even spoiled, endangering the patient's health. Therefore, drugs must have intact sealed 

packaging throughout their entire shelf life, and drug packaging materials must undergo professional and rigorous 

sealing performance testing. Testing the sealing performance of drug packaging materials is to test the sealing reliability 

of flexible packaging, packaging bottles, etc. Through this test, it can ensure that the entire product packaging is sealed

 completely without leakage. In the pharmaceutical industry, it is essential to conduct sealing tests on the packaging of

 various drugs produced, which will directly determine whether the quality of the drugs meets the standards and whether

 they will pose a threat to human safety.

So, what are the materials that need to be tested for sealing in drug packaging?

There are many drugs in the pharmaceutical industry that need to be tested for packaging sealing, and the common ones 

are the following three categories:

1. Sealed containers: penicillin bottles, ampoules, syringes, oral liquids, sterile bags, infusion bags/bottles, water injections,

   powder injections, BFS bottles, API bottles, BPC bottles, FFS bottles, and other sealed containers of any shape, material, or size.

2. Bubble wrap packaging: Samples of powders, tablets, capsules, contact lenses, etc. packaged in bubble wrap form.

3. Small headspace packaging: Packaging with extremely small headspace, such as granule packaging and low-dose powder

 packaging.

In addition, there are sterile products and cooking bags in the field of medical equipment.

With the increasing standardization of drug packaging material management, the sealing of drug packaging materials must 

refer to relevant national drug packaging material testing standards, such as: GB/T 15171、ASTM D3078、GB/T 27728、

YBBOOl12002-2015、YBB00122002-2015、YBB00262002-2015， Use professional pharmaceutical packaging sealing testing 

equipment.